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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GYS1 All Species: 5.15
Human Site: S614 Identified Species: 8.1
UniProt: P13807 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P13807 NP_002094.2 737 83786 S614 S A R H M A L S K A F P E H F
Chimpanzee Pan troglodytes XP_520790 703 80912 E590 I I Q R N R T E R L S D L L D
Rhesus Macaque Macaca mulatta Q8MJ26 737 83768 S614 S A R H M A L S K A F P E H F
Dog Lupus familis XP_534869 703 80957 E590 I I Q R N R T E R L S D L L D
Cat Felis silvestris
Mouse Mus musculus Q9Z1E4 738 83908 A614 S A R H M A L A K A F P D H F
Rat Rattus norvegicus A2RRU1 738 84053 A614 S A R H M A L A K A F P D H F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505471 733 83148 A614 F A R H M A L A K A F P D Y F
Chicken Gallus gallus XP_416432 704 81032 R589 Q R I I Q R N R T E R L S D L
Frog Xenopus laevis NP_001084863 702 80811 R589 Q R I I Q R N R T E R L S D L
Zebra Danio Brachydanio rerio NP_957474 700 80455 R588 Q R I I Q R N R T E R L S D L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFC8 709 81735 I589 Y I V D R R Y I G L E N S V Q
Honey Bee Apis mellifera XP_624707 692 79590 L579 L E S S V Q Q L A Q Y M F D F
Nematode Worm Caenorhab. elegans Q9U2D9 672 76441 E561 G F G C F M Q E H V E D H E Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23337 708 80492 L597 T E R L S D L L D W K R M G L
Red Bread Mold Neurospora crassa O93869 706 80888 Y595 W K R M G M E Y V K A R Q L A
Conservation
Percent
Protein Identity: 100 68.6 99 69.3 N.A. 96.6 96.6 N.A. 90 71 69.3 78.1 N.A. 55 56.4 49.6 N.A.
Protein Similarity: 100 81.8 99.5 82.5 N.A. 98.5 98.5 N.A. 95.2 84.1 82.5 86.5 N.A. 71 70.1 65.8 N.A.
P-Site Identity: 100 0 100 0 N.A. 86.6 86.6 N.A. 73.3 0 0 0 N.A. 0 6.6 0 N.A.
P-Site Similarity: 100 13.3 100 13.3 N.A. 100 100 N.A. 93.3 0 0 0 N.A. 0 20 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 50 51.1
Protein Similarity: N.A. N.A. N.A. N.A. 67.1 67
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 34 0 0 0 34 0 20 7 34 7 0 0 0 7 % A
% Cys: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 7 0 0 7 0 0 20 20 27 14 % D
% Glu: 0 14 0 0 0 0 7 20 0 20 14 0 14 7 0 % E
% Phe: 7 7 0 0 7 0 0 0 0 0 34 0 7 0 40 % F
% Gly: 7 0 7 0 7 0 0 0 7 0 0 0 0 7 0 % G
% His: 0 0 0 34 0 0 0 0 7 0 0 0 7 27 0 % H
% Ile: 14 20 20 20 0 0 0 7 0 0 0 0 0 0 0 % I
% Lys: 0 7 0 0 0 0 0 0 34 7 7 0 0 0 0 % K
% Leu: 7 0 0 7 0 0 40 14 0 20 0 20 14 20 27 % L
% Met: 0 0 0 7 34 14 0 0 0 0 0 7 7 0 0 % M
% Asn: 0 0 0 0 14 0 20 0 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 34 0 0 0 % P
% Gln: 20 0 14 0 20 7 14 0 0 7 0 0 7 0 14 % Q
% Arg: 0 20 47 14 7 40 0 20 14 0 20 14 0 0 0 % R
% Ser: 27 0 7 7 7 0 0 14 0 0 14 0 27 0 0 % S
% Thr: 7 0 0 0 0 0 14 0 20 0 0 0 0 0 0 % T
% Val: 0 0 7 0 7 0 0 0 7 7 0 0 0 7 0 % V
% Trp: 7 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 7 7 0 0 7 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _